Imatinib (Gleevec), a tyrosine-kinase inhibitor of EGFR, was initially invented in the late 1990s by a biochemist, Nicholas Lyndon, and then approved by the FDA in 2001 for the treatment of multiple cancers, most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML)[22]. This evidence concerns the gene EGFR and chronic myelogenous leukemia, BCR-ABL1 positive.