TNF and obesity due to melanocortin 4 receptor deficiency: The elevated pro-inflammatory factors, such as C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6)[1], play a central role in metabolic diseases, including obesity, type 2 diabetes (T2DM), metabolic syndrome (MS), cardiovascular disease[2,3] (CVD) and nonalcoholic fatty liver disease (NAFLD)[4].