Furthermore, we identified erb-b2 receptor tyrosine kinase 2 (ERBB2) as an upstream inhibitor of several genes including ADAM19, CGB8, FN1, and FSTL3. ERBB2 is involved in the mitogen-activated protein kinase signalling pathway and its role in cancer development and evolution has been shown [33]. The gene discussed is FSTL3; the disease is cancer.