IGFBP1 and cancer: The highest scoring IPA network of the molecular relationships between differentially expressed genes revealed the involvement of the molecules in top diseases and functions such as embryonic development, organismal development, and cancer, where different genes including: AREG, CCL2, FN1, HLA-DRB1, IGFBP1, IL1R2, MMP12, PRL, and TNFSF10 were intertwining (IPA score of 46; Fig 3A).