SPP1 and Familial prostate cancer: This is evidenced by the fact that reconstitution of miR-466 caused a marked downregulation of RUNX2 target genes such as osteopontin, osteocalcin, ANGPT1, ANGPT4, MMP11 including Fyn, pAkt, FAK and vimentin that are involved in migration, invasion, angiogenesis, EMT and metastasis.15, 16, 17, 34, 35 Thus, miR-466 orchestrates the functional activities of RUNX2 by its convergent action on RUNX2 and its downstream target gene network to control prostate cancer bone metastasis.