In conclusion, for the first time we provide evidence that: (i) miR-466 is an under-expressed metastasis suppressor miRNA in PCa; (ii) miR-466 is biologically relevant and has biomarker potential in PCa; (iii) miR-466 directly regulates RUNX2, a key regulator of bone metastasis; (iv) miR-466 overexpression interrupts RUNX2 integrated network of genes required to maintain PCa growth and bone metastasis. The gene discussed is RUNX2; the disease is posterior cortical atrophy.