CASP6 and Alzheimer disease: For example, enhancing p300 HAT activity by upregulating PKCδ expression promotes the apoptosis of dopaminergic neurons.51 Similarly, Tip60 HAT activity mediates APP-induced lethality and apoptosis in neurons in the AD model.52 Furthermore, CBP/p300 cooperating with NF-Y and FOXO3a triggers apoptosis in sympathetic neurons.53 CBP promotes apoptosis in normal CGNs but loss of CBP by Caspase 6 facilitates neuronal apoptosis following potassium deprivation,54 suggesting that CBP exhibits different roles in regulating neuronal fate in different conditions.