FAS and systemic sclerosis: In a genetic model of SSc, Akiyama and colleagues found that allogeneic BMSCs remarkably reduced hyperdermal thickness and autoantibodies, and MSCs-mediated T cell apoptosis by FAS/FAS Ligand death pathway triggered macrophages to produce TGF-β1 leading to up-regulation of Treg population (Figure 1 and Table 3).