NOS2 and nervous system disorder: While acute antagonism of iNOS with pharmacological [12,30,32], molecular [12,27], or transgenic [31] approaches, has demonstrated beneficial impacts after SCI, there is evidence from other neurological disease and injury paradigms, including traumatic brain injury (TBI), nerve injury, and experimental autoimmune encephalitis (EAE), that the complete ablation of iNOS, particularly for longer durations, can be deleterious.