Treatment of androgen-dependent (LNCaP) and androgen-independent (LNCaP-AR and DU145) human PCa cell lines with PFE and PJ displayed decreased expression of genes involved in androgen biosynthesis, such as 3β-hydroxysteroid dehydrogenase type 2, aldo-keto reductase family 1 member C3, steroid 5α reductase type 1, and AR [51]. The gene discussed is AR; the disease is posterior cortical atrophy.