Additionally, genetic disruption of 5-LO in a mouse model of ethanol-induced oral carcinoma resulted in activation of COX-2 and an increase in COX-2 metabolites thought to be produced mainly by inflammatory cells [114,161] This evidence suggests dual inhibition of both these pathways may have a superior anti-cancer effect in the suppression of angiogenesis. This evidence concerns the gene PTGS2 and lip and oral cavity carcinoma.