ALOX5 and metabolic disease: Given the similar histology of obese adipose tissue inflammation in both metabolic disease and cancer [165], the evidenced role of adipose-tissue 5-LO signalling in metabolic disease [170,172] and the role of 5-LO in components of the TME [37], it is possible, although not yet investigated, that adipose-tissue derived 5-LO activity plays a role in the TME.