ALOX5 and esophageal adenocarcinoma: For example, it has recently been demonstrated that immune stromal expression of 5-LO and other distal enzymes involved in the synthesis of 5-LO-derived leukotrienes were increased in human oesophageal adenocarcinoma compared to normal oesophagus, suggesting a role of the 5-LO signalling specifically in the TME during tumour development and progression [34].