For example, incorrect neuronal migration, caused by a Disc1 single-nucleotide polymorphism, leads to a deficiency in the grey matter volume in some brain areas in patients with major depressive disorders [80], while that caused by polymorphisms in dyx1c1 or dcdc2, leads to changes in temporo-parietal white matter structure [156]. The gene discussed is DISC1; the disease is major depressive disorder.