APP and early-onset autosomal dominant Alzheimer disease: These disease-specific proteins include the prion protein (PrPsc) of Creutzfeldt-Jakob disease, α-synuclein, which is the most abundant protein in Lewy Body inclusions of Parkinson’s disease (PD), superoxide dismutase (SOD) in Amyotrophic Lateral Sclerosis, and in Alzheimer’s disease (AD) hyper-phosphorylated tau makes up neurofibrillary tangles, while cleavage of amyloid precursor protein (APP) causes parenchymal deposition of amyloid β peptide (Aβ) in the form of amyloid plaques [1].