While patients with abetalipoproteinaemia are unable to form chylomicrons essential for absorption of vitamin E, those treated with PCSK9 inhibition experience increased catabolism of LDL, which is thought unlikely to impair absorption or distribution of vitamin E. Despite the requirement of free cholesterol for steroid hormone synthesis, no evidence of impairment in adrenal or gonadal steroid hormone synthesis was found with PCSK9 inhibition, even in patients who experienced LDL reductions to <0.4 mmol/L (<15 mg/dL) [37]. The gene discussed is PCSK9; the disease is abetalipoproteinemia.