PCSK9 and Hypercholesterolemia: Similarly, a post hoc analysis performed on data from the Long-term Safety and Tolerability of Alirocumab in High Cardiovascular Risk Patients with Hypercholesterolemia Not Adequately Controlled with Their Lipid Modifying Therapy (ODYSSEY LONG TERM) study also suggested a beneficial effect of PCSK9 inhibition on major CV events compared with placebo (hazard ratio 0.52, 95% CI 0.31–0.90).