TF and Sepsis: The involvement of NET-bound TF, which is the main in vivo initiator of coagulation (87), in NET-dependent thromboinflammation has been shown in several studies, since TF has been identified in NETs released in neutrophils from patients with sepsis, APS, AAV, or myocardial infarction (12, 14, 16, 74) or in a mouse model of DVT (64).