For example, tissue factor (TF) was detected on NETs in vein and arterial thrombosis (16, 64, 65), interleukin 1 beta (IL-1β) in gouty arthritis (24) and FMF (23), interleukin 17 (IL-17) in psoriasis (66) and pulmonary fibrosis (33), antimicrobial peptide LL-37 in systemic lupus erythematosus (SLE) (19), and PAD4 in rheumatoid arthritis (RA) (67). This evidence concerns the gene IL1B and rheumatoid arthritis.