APC and Familial adenomatous polyposis: Surprisingly, these results are in substantial disagreement with previous reports showing that mutations of the Apc gene, encoding for a protein whose main role is to bind β-catenin, a mediator of the Wnt signaling pathway, are actually associated with increased BMD, both in animal models and in patients with Familial Adenomatous Polyposis (Holmen et al., 2005; Miclea et al., 2010).