BCA2 is expressed endogenously in most tissues, but it is particularly upregulated in NK cells, CD8+ T cells, CD4+ T cells, dendritic cells, and monocytes, suggesting that its antiviral properties are of particular relevance for HIV-1 infection (available in NCBI Ace View [https://www.ncbi.nlm.nih.gov/ieb/research/acembly/av.cgi?db=human&term=RNF115] and the Human Protein Atlas databases [http://www.proteinatlas.org/search/rnf115]). Here, CD4 is linked to HIV-1 infection.