MAPT and Alzheimer disease: Progressively increasing regional 18F-AV-1451 binding in Alzheimer’s disease has also been associated with Braak staging of neurofibrillary tau pathology (Schöll et al., 2016; Schwarz et al., 2016), while 18F-AV-1451 PET binding patterns mirror the clinical and neuro-anatomical variability in the Alzheimer’s disease spectrum (Ossenkoppele et al., 2016).