MAPT and early-onset autosomal dominant Alzheimer disease: Neuropathological data with autoradiography have suggested that the 18F-AV-1451 tracer displays strong binding to paired helical filaments characteristic of Alzheimer’s disease (e.g. intra-neuronal and extra-neuronal neurofibrillary tangles and dystrophic neurites), but it does not bind so specifically to the straight tau filaments that are more typical of PSP and non-Alzheimer’s disease tauopathies (e.g. cortico-basal degeneration) (Marquié et al., 2015).