In view of the suggested effect of off-target binding, we also examined 18F-AV-1451 uptake in relation to AT8 immunohistochemistry of hyperphosphorylated tau protein and tinctorial stain for neuromelanin, in post-mortem sections from a patient with Alzheimer’s disease, PSP, and a similarly aged control from the Cambridge Brain Bank. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.