MAPT and nervous system disorder: Furthermore, tau pathology is common in other neurological diseases such as fronto-temporal dementia (Hodges et al., 2004), corticobasal degeneration, and may modulate the course of Parkinson’s disease (Spillantini and Goedert, 2001; Irwin et al., 2013), Huntington’s disease (Fernández-Nogales et al., 2014), and multiple sclerosis (Anderson et al., 2008).