Some lentiviruses have evolved countermeasures against SAMHD1; for example, the HIV‐2/SIVsm lineage encodes the Vpx protein that degrades SAMHD1 and allows infection of otherwise SAMHD1‐positive target cells (Kaushik et al, 2009; Hrecka et al, 2011; Laguette et al, 2011). The gene discussed is SAMHD1; the disease is infection.