Furthermore, exogenously induced degradation of SAMHD1 by co‐infection with SIVmac virus‐like particles bearing Vpx (VLP‐vpx) (Fig 2B), or depletion of SAMHD1 by siRNA transfection (Fig 2C) led to a 10‐fold increase in HIV‐1 infectivity specifically in unstimulated MDM, with no change in infection in the permissive stimulated MDM where SAMHD1 is phosphorylated and thus already inactive against HIV‐1. Here, SAMHD1 is linked to coinfection.