Two very strong cis-eQTLs were confirmed at the VAMP5-VAMP8-GGCX locus, targeting cis-eGenes VAMP8 and GGCX. The CAD/MI risk SNP rs7568458 was in tight LD with our lead eQTL for VAMP8 and for GGCX. The gene GGCX codes for a protein that carboxylates glutamate residues of vitamin K-dependent proteins and in turn can affect coagulation and may prevent of vascular calcification and inflammation [33]. The gene discussed is PROS1; the disease is coronary artery disorder.