The lead CAD/MI risk SNP at the VAMP5-VAMP8-GGCX locus (rs7568458) was also in tight LD with trans-eQTLs targeting five eGenes (CASP5, DPEP3, CRISPLD2, SLC26A8, PKN2; Additional file 1: Table S12). The gene discussed is CRISPLD2; the disease is coronary artery disorder.