THBS2 and prostate cancer: However, the expression profile of TSP-2 is quite controversial, which is down-regulated in cervical cancer [9] and ovarian cancer [16], while it is overexpressed in oral cavity squamous cell carcinoma [17], pulmonary adenocarcinoma [18], and prostate cancer [19], suggesting that TSP-2 may play another role rather than anti-angiogenesis.