Moreover, numerous autosomal recessive PD genes, including Parkin (PARK2), PINK1 (PARK6), DJ-1 (PARK7) and Fbxo7 (PARK15) were found to be implicated in mitophagy, which is the degradation of dysfunctional mitochondria by autophagy [31, 44]. This evidence concerns the gene PRKN and Parkinson disease.