RET and medullary thyroid gland carcinoma: Considering that RETM918T is the highest risk mutation with strong migratory abilities [2], and is also the most common mutation detected in 57% (8/14) of patients in the pN1p/cM1 MTC stage [40], these results support the role of miR-182 as a contributor of RET oncogene-induced metastatic development.