Our studies identified a novel regulatory niche between BAP1 and lncRNA nuclear paraspeckle assembly transcript 1 (NEAT-1) in modulating CCA phenotype and chemotherapeutic responses to gemcitabine individually and in combination with target-specific agents such as EZH2 or PARP inhibitor, GSK126 or olaparib, respectively. Here, EZH2 is linked to cholangiocarcinoma.