The importance of NKT cells during viral infections becomes clear given that several viruses like Lymphocytic Choriomeningitis Virus (LCMV), Cytomegalovirus (CMV), vesicular stomatitis virus, vaccinia virus, Herpes Simplex Virus (HSV)-1 and Human Immunodeficiency Virus (HIV)-1 disrupt CD1d expression on infected target cells to evade antiviral effects of NKT cells [10–13]. Here, CD1D is linked to viral infectious disease.