Three scFvs (ALS-TDP6, ALS-TDP10 and ALS-TDP14) reacted with all 5 ALS samples, five (ALS-TDP4, ALS-TDP5, ALS-TDP9, ALS-TDP15 and AD-TDP3) reacted with 4 of the 5 ALS samples and four (ALS-TDP11, ALS-TDP13, ALS-TDP20 and AD-TDP1) reacted with 3 of the 5 ALS cases. The gene discussed is TDP1; the disease is Alzheimer disease.