Also, since TDP-43 pathology is not unique to ALS and FTD, but has been detected in other neurodegenerative disease including ~ 57% of individuals with AD, 19% of PD cases, 45% of individuals having dementia with Lewy bodies (DLB) and 100% of tested Huntington’s cases [12, 13, 39, 43–47], we also intend to screen the scFvs for cross reactivity with these other diseases. Here, TARDBP is linked to frontotemporal dementia.