TARDBP and Alzheimer disease: We randomly selected five of the previously isolated scFvs against ALS TDP-43 variants (ALS-TDP6, ALS-TDP13, ALS-TDP15, ALS-TDP18 and AD-TDP3) for use as capture antibodies to assay TDP-43 immunoprecipitated from ALS, FTD and control tissue samples (Fig. 3a) and homogenized human brain tissue instead of immunoprecipitated proteins (Fig. 3b).