In turn, variables independently associated with plasma suPAR levels are presented in section B and variables predicting plasma endothelial dysfunction markers in patients with CKD are shown in section C. Age and F1 + 2 levels were the independent variables significantly associated with vWF concentrations in CKD, whereas PAP, IS and suPAR independently affected increased TM levels. The gene discussed is VWF; the disease is endothelial dysfunction.