TP53 and cancer: We focused our analysis on 430 genes from several well-known cancer-related pathways: PI3K [25, 26], p53 signaling [27–29], VEGF [30, 31], Hedgehog signaling [32, 33], ErbB signaling [34, 35], Ras signaling [36, 37] and Ion-channel family [38, 39].