We herein studied the effect of oxaliplatin on the tNOX protein and assessed the underlying mechanism in three cell lines derived from human stomach cancers: AGS (gastric adenocarcinoma), MKN45 (from the lymph node of a moderately differentiated stomach adenocarcinoma), and TMK-1 (from a poorly differentiated adenocarcinoma). The gene discussed is ENOX2; the disease is gastric cancer.