AKT1 and hepatocellular carcinoma: We tested the in vivo effects of GSK690693 in SMMC-7721 or Hep3B cells when they were co-cultured with EA.hy926 cells that develop angiogenesis of HCC .We found that treatment with GSK690693 substantially reduced the activation of PI3K/AKT in endothelial cells in a time-dependent manner.