To confirm that S100A9 is regulated by CBX6 in human HCC tissues, we measured S100A9 mRNA levels in 50 pairs of HCC tissues and matched nontumor tissues, as shown in Figure 1B,and found that S100A9 mRNA levels were significantly higher in the HCC tissue samples than in the primary nontumor tissue samples (Figure 5G). Here, S100A9 is linked to hepatocellular carcinoma.