Regarding the mechanism underlying the involvement of CBX6 in HCC, gene microarray analysis of a CBX6-knockdown cell line revealed that S100A9 expression was low, suggesting that CBX6 plays an important role in HCC progression through S100A9/NF-κB/MAPK signaling and may be useful as a future HCC therapy. The gene discussed is S100A9; the disease is hepatocellular carcinoma.