Recently, the pivotal role of miRNAs in the chemotherapy of variety of cancers have been widely reported, such as miR-135a promotes the gastric cancer resistance to oxaliplatin through suppressing the E2F1/Sp1/DAPK2 pathway signaling [7]; overexpression of miR-126 could increase chemosensitivity in drug-resistant gastric cancer cells by targeting EZH2 [8]. This evidence concerns the gene SP1 and gastric cancer.