MiR-29b belongs to the miR-29s family, which was a subclass of “epi-miRNAs”, as they target a subset of epigenetic regulators such as DNA methyltransferases (DNMTs), histone deacetylases (HDACs), and revert aberrant epigenetic alterations in cancers [11]; For example miR-29b could turn off the synthesis of key OBL-inhibitor proteins, TGFβ3 and HDAC4, allowing the expression of Runx2 and suppression of the Wnt pathway inhibitor catenin beta interacting protein 1 (CTNNBIP1), thus contributes to the osteoblast differentiation [12]. The gene discussed is RUNX2; the disease is cancer.