Real-time PCR showed that in 5-week-old mice, Notch1 and Notch3 mRNAs are upregulated in normal thymocytes from Lck-Dlx5 mice when compared to those of normal thymic T cells from age-matched WT littermates or Lck-MyrAkt2 mice, and their expression was further augmented in lymphomas from Lck-Dlx5 mice (Figure 6A). The gene discussed is NOTCH3; the disease is lymphoma.