NOTCH3 and acute lymphoblastic leukemia: Our study of human pediatric T-ALL revealed overexpression of DLX5 in about 20% cases, with co-upregulation of NOTCH1 and, to a lesser extent, NOTCH3. Intriguingly, not all homeobox genes behave in a similar manner, as a recent report showed that TLX1 actually inhibits NOTCH3 expression [32].