To determine if the findings in our murine model have clinical relevance, we performed real-time PCR on 15 pediatric T-ALL specimens and found that 3 samples had high levels of expression of DLX5. Notably, these three samples also had elevated expression of NOTCH1, and in one case, NOTCH3 (Figure 2F). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.