Notably, Soulier and colleagues determined that the HOXA-related subgroup of T-ALL is characterized by high levels of expression of several genes known to be critical for T-cell differentiation and/or oncogenesis, including NOTCH3 [3], which we found to be transcriptionally regulated by Dlx5 in lymphomas from Lck-Dlx5 mice. This evidence concerns the gene NOTCH3 and acute lymphoblastic leukemia.