NOTCH1 and lymphoma: While lymphoma cells from Lck-Dlx5 mice were sensitive to γ-secretase inhibitors, those from Lck-MyrAkt2 mice (most of which did not show over expression of Notch1/3; Figure 2) were resistant, further strengthening our contention that Notch signaling is a driving force in Dlx5-mediated lymphomagenesis.