Moreover, combinational treatment of Lck-Dlx5 tumor cells with GSK690693 and DAPT or γ-secretase inhibitor XXI resulted in a marked increase in cell death as shown by augmentation of the sub-G1 peak and by activation of caspase-3 (Figure 4I, 4J; Supplementary Figure 4H). The gene discussed is DLX5; the disease is neoplasm.