To determine if the findings in our murine model have clinical relevance, we performed real-time PCR on 15 pediatric T-ALL specimens and found that 3 samples had high levels of expression of DLX5. Notably, these three samples also had elevated expression of NOTCH1, and in one case, NOTCH3 (Figure 2F). Here, NOTCH3 is linked to acute lymphoblastic leukemia.