Other factors associated with the occurrence of severe neutropenia were: initiating ART between 2009 and 2011 (aHR = 0.73; 95% CI: 0.60–0.91) or between 2012 and 2014 (aHR = 0.55; 95% CI: 0.44–0.69) compared to initiation before 2005; an advanced clinical stage (CDC 3 or WHO 4) at ART initiation (aHR = 1.21; 95% CI: 1.02–1.44); and time-updated CD4 count <350 cells/mm3 (aHR = 1.26; 95% CI: 1.07–1.49) compared with CD4 count ≥350cells/mm3. This evidence concerns the gene CD4 and Decreased total neutrophil count.