Based on the patient's symptoms including palpitations, insomnia, diarrhea, weight loss, and lab results of elevated thyroid hormone level a marked elevated serum calcium level, and lower BMD, a diagnosis of Graves’ disease, hyperthyroidism associated hypercalcemia and osteoporosis was made after further excluding the others causes lead to hypercalcemia. This evidence concerns the gene TG and Hypercalcemia.