The serum C-reactive protein (CRP) is an acute phase protein found in the blood stream the levels of which rise in response to inflammation and it has been extensively studied in coronary artery diseases, malignant tumors (including hepatocellular carcinoma), tissue necrosis, and bacterial translocation.[5–8] Several studies have been performed on the association of CRP with the severity of inflammation in liver disease, such as fatty liver and chronic hepatitis C.[9–12]. This evidence concerns the gene CRP and hepatocellular carcinoma.