These results are in agreement with studies done on osteocalcin and NTx.[48] The exact mechanism of osteocalcin which is produced by osteoblasts during the bone formation process in bone is still unclear.[19] Bone degradation process involves breakdown of type I collagen as carboxy-terminal telopeptides of collagen type I and NTx, which are used to determine the rate of bone resorption.[20,49] The previous reports are in agreement with our finding since NTx was higher in the women with osteoporosis than healthy women. This evidence concerns the gene BGLAP and osteoporosis.