TNFSF11 and osteoporosis: An obvious relationship between inflammation and osteoporosis was seen in rheumatoid arthritis, whereby proinflammatory cytokines were released causing bone loss around the affected joints and increase of bone turnover markers (BTMs).[16,17] Proinflammatory cytokines may contribute to bone loss by osteoclasts which activated by receptor activator of nuclear factor κB ligand (RANKL) leading to osteoporosis.[18]