In ER-negative disease, it was shown that CD8 was prognostic for RFS in the presence of high FAS expression (HR 0.42, 95% CI 0.19-0.96, p=0.04), but not with low FAS expression (HR 0.54, 95% CI 0.23-1.29, p=0.17), with a HR for interaction of 0.80, (p=0.71) (Figure 5A,B). This evidence concerns the gene FAS and glycogen storage disease VI.