RUNX2 and head and neck squamous cell carcinoma: In paired HNSCC samples of both real-time PCR and IHC results reveal that RUNX2 mRNA (Fig. 3G, 22/43 = 51.0%, p < 0.001) and protein (Fig. 3H and I, 30/38 = 78.9%, p < 0.001) are significantly up-regulated in clinical HNSCC tumors.