JUP and arrhythmogenic right ventricular cardiomyopathy: To date, 13 genes have been reported in patients with ARVC, and desmosomal genes account for more than 50% of all cases, including plakoglobin (JUP), plakophilin-2 (PKP2), desmoplakin (DSP), desmoglein-2 (DSG2), and desmocollin-2 (DSC2)3.