This expression signature observed in the tumor samples from HoipΔhep mice resembles that of the subclass A and G1‐G3 of human HCC described by Thorgeirsson's and Zucman‐Rossi's groups, respectively, which are correlated with poor prognosis.27, 28 Thus, HOIP deletion results in late formation of hepatic tumor nodules with overexpressed cell cycle regulatory genes. This evidence concerns the gene RNF31 and neoplasm.