NFKB1 and cholestasis: For instance, hepatocyte apoptosis and hepatocarcinogenesis due to LPC‐specific TAK1 deficiency are mediated by caspase‐8 in those cells, while cholestasis was induced by the necroptosis inducer receptor–interacting protein kinase (RIPK3).11 Furthermore, transforming growth factor β–activated kinase 1 and the IKKα–IKKβ–NEMO complex have been shown to suppress cell death signaling independently of their role in activating NF‐κB in hepatocytes and other cell types.12, 13 Thus, deregulated cell death and/or NF‐κB signaling in hepatocytes can result in liver inflammation and carcinogenesis.