However, there is an increasing trend of patients suffering from HCC, particularly in the Western world, associated with obesity and metabolic syndrome but without prior history of cirrhosis.42 In our mouse model, tumor‐bearing HOIP‐deficient livers exhibited steatotic features, which may indicate some metabolic alterations in hepatocytes. This evidence concerns the gene RNF31 and obesity due to melanocortin 4 receptor deficiency.