In addition to some genes that were previously discussed in the above paragraphs (ATG7, NIPA1, CACNA1H, KCNIP4, KCNQ5, KCNB2, SLC1A7, CO3, MAPK8IP3, ANXA5, HFE, FMN2, NEFH, EPHA3), two interesting segmental duplications in TRDN and CHMP6 were found in some cases of ALS and in none of patient controls (Supplementary Table 1) [84, 138, 165]. This evidence concerns the gene HFE and amyotrophic lateral sclerosis.