Moreover, many of these genes show a functional correlation also with the most known causative ALS genes (e.g., SOD1, ALS2, SETX, FUS, TARDBP), supporting the evidence that multiple common and rare CNVs may exert their pathogenic effect by different multifactorial combinations, jointly contributing to the genetic susceptibility of ALS (Fig. 6). This evidence concerns the gene SETX and amyotrophic lateral sclerosis.