Multiple GWAS studies have described ALS-specific gains and losses in several genes encoding proteins involved in synaptic transmission and the regulation of neuronal action potential (KCNIP4, KCNB2, KCNQ5, GRIK1, GRIK2, ATXN1, BAIAP2, CPLX1, CACNA1H, SLC1A7) (Tables 1 and 2 and Supplementary Table 1) [110, 117]. The gene discussed is GRIK1; the disease is amyotrophic lateral sclerosis.