To this regard, aberrant gene expression and copy number variations in genes involved in neuroinflammation and cellular response to injurious stimuli (FOXO3, HFE, GSDMD) have been identified in ALS patients with respect to controls (Table 1 and Supplementary Table 1) [99, 110, 117]. The gene discussed is HFE; the disease is amyotrophic lateral sclerosis.