Different CNVs in some genes that code for potassium and calcium channels (KCNIP4, KCNB2, KCNQ5, CACNA1H) were found in ALS patients and seem to have a particular interest in the deciphering the genetic cause of ALS (Tables 1 and 2 and Fig. 4). This evidence concerns the gene KCNB2 and amyotrophic lateral sclerosis.