Recently, mutations of the DEPDC5 (DEP domain containing 5, involved in g-protein signalling) gene have been demonstrated in patients with cortical dysplasia and in up to 12% of small families of patients with familial focal epilepsy phenotypes, including ADNFLE without demonstrable lesions [101–103]. The gene discussed is DEPDC5; the disease is autosomal dominant nocturnal frontal lobe epilepsy.