Further supporting this hypothesis, it is well known that TLR2 and TLR4 are crucial in host defense against several bacterial pathogens that, like B. microti, cause sepsis like Staphylococcus aureus, Streptococcus pneumoniae (Takeuchi et al., 2000; Dessing et al., 2008), Klebsiella pneumoniae (Schurr et al., 2005), Haemophillus influenza (Wang et al., 2002) and Acinetobacter baumanii (Knapp et al., 2006). This evidence concerns the gene TLR4 and Sepsis.