SOD1 and obesity due to melanocortin 4 receptor deficiency: A controlled study has shown that topical application of superoxide dismutase (SOD) fused with the TAT peptide (TAT-SOD), to various acupoints along the meridian lines used in acupuncture to treat obesity, leads to significant weight loss [15], monitoring the effects of acupoint antioxidant intervention by measuring electrical potential difference along the meridian [16].