However, although the NLRP3 inflammasome has been shown to be highly related to the pathogenesis and progression of IBD and the crosstalk between autophagy and the NLRP3 inflammasome may probably provide a potential and promising therapeutic target for the treatment of IBD, yet the underlying mechanisms of IBD are not completely clear, and there is still a long way to go. Here, NLRP3 is linked to inflammatory bowel disease.