We found that exposure to eosinophils from both the asthma and control groups increased WNT-5a gene expression in ASM cells, but the asthma group showed a significantly higher effect (asthma group increase in gene expression of the ligand: 2.95 ± 0.46–fold vs. control group increase: 1.79 ± 0.16–fold; p < 0.05). The gene discussed is WNT5A; the disease is asthma.