Accumulating evidence suggests that a large number of pathogens and subsequent the production of a large quantity of inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), reactive oxygen species (ROS) and nitric oxide (NO) etc., mainly through nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, gets involved in the pathogenesis of sepsis (Carneiro et al., 2013; Liang et al., 2014). This evidence concerns the gene TNF and Sepsis.