Emodin was reported to protect against concanavalin A-induced hepatitis in mice through inhibiting activation of the p38 MAPK-NF-κB signaling pathway (Xue J. et al., 2015), indicating that anti-sepsis effects of Emodin may be closely related with p38 MAPK-NF-κB signaling pathway. The gene discussed is NFKB1; the disease is hepatitis A virus infection.