LRRK2 and Parkinson disease: Previous studies reported that the LRRK2-R1441 mutant causes disrupted neurite outgrowth, leads to decreased neuritic branching in PD models using cultured cell lines or primary neurons (MacLeod et al., 2006; Heo et al., 2010; Cherra et al., 2013; Tagliaferro et al., 2015).