These changes in human CX3CR1 decrease FKN affinity (McDermott et al., 2003) and several studies support a role for CX3CR1M280 in susceptibility to age-related macular degeneration (Tuo et al., 2004; Chan et al., 2005; Brión et al., 2011; Schaumberg et al., 2014). This evidence concerns the gene CX3CL1 and age-related macular degeneration.