CX3CL1 and diabetes mellitus: To limit the toxicity of STZ-induced diabetes in combination with systemic inflammation we only performed a 2 day LPS protocol in diabetic FKN-KO mice since we observed a similar trend (data not shown; Table 2) of increased microglial cellularity and fibrinogen leakage as observed in 4 day LPS-treated CX3CR1-KO mice (Figure 3).