PRRT2 and Hyperglycemia: A hyperglycemic state has been associated with acute stroke and hyperglycemia has independently been found to induce NOX activation as well (Wang et al., 2013; Shao and Bayraktutan, 2014) Hyperglycemic states have been found to potentiate blood-brain barrier breakdown through endothelial apoptosis facilitated by PKC-induced NOX activation of apoptotic pathways and through tight junction dysfunction due to NOX-induced MMP induction (Shao and Bayraktutan, 2013, 2014).