APP and Alzheimer disease: We first reported that APP processing by MT1-MMP and MT5-MMP leads to an increase of Aβ levels in a heterologous cell system (Py et al., 2014; Baranger et al., 2016b), and most important, we demonstrated the contribution of MT5-MMP to AD pathogenesis in the 5xFAD transgenic mouse model of AD (Baranger et al., 2016b).